期刊
ADVANCED MATERIALS
卷 24, 期 28, 页码 3779-3802出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201200653
关键词
medical imaging; drug delivery; nanoparticles; targeting; superparamagnetic nanoparticles; micelles; porous silicon; mesoporous silica; liposomes; viral nanoparticles; nanotubes
类别
资金
- Converging Research Center Program of the Ministry of Education, Science and Technology, Korea [2011K000864]
- National Cancer Institute of the National Institutes of Health (NIH BRP) [R01CA124427-01]
- National Science Foundation, USA [DMR-0806859]
- Ministry of Science, ICT & Future Planning, Republic of Korea [KIOST01] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
There is currently considerable effort to incorporate both diagnostic and therapeutic functions into a single nanoscale system for the more effective treatment of cancer. Nanoparticles have great potential to achieve such dual functions, particularly if more than one type of nanostructure can be incorporated in a nanoassembly, referred to in this review as a hybrid nanoparticle. Here we review recent developments in the synthesis and evaluation of such hybrid nanoparticles based on two design strategies (barge vs. tanker), in which liposomal, micellar, porous silica, polymeric, viral, noble metal, and nanotube systems are incorporated either within (barge) or at the surface of (tanker) a nanoparticle. We highlight the design factors that should be considered to obtain effective nanodevices for cancer detection and treatment.
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