期刊
ADVANCED MATERIALS
卷 24, 期 48, 页码 6433-6437出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201201742
关键词
coordination bond; pH-responsive nanoparticles; mesoporous silica; coordination polymers; drug delivery
类别
资金
- 973 project of China [2009CB930403]
Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H+ stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.
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