期刊
ADVANCED MATERIALS
卷 24, 期 45, 页码 6010-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201201484
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资金
- UCSD Funds
- [NIH R21-EB012758]
- [NIH K99-CA153935]
- [NIH U54-CA119335]
- [NIH P50-CA128346]
Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.
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