期刊
ADVANCED MATERIALS
卷 24, 期 31, 页码 4261-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201104891
关键词
gold nanoparticles; DNA compaction; DNA denaturing; cationic ligands; DNA-nanoparticle interactions
类别
资金
- ASCR, Office of Science, US Department of Energy
- U.S. National Science Foundation [CMMI-1150682]
- NSF's Research Triangle MRSEC [DMR-1121107]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1150682] Funding Source: National Science Foundation
Weakly charged cationic nanoparticles cause structural changes including local denaturing and compaction to DNA under mild conditions. The charged ligands bind to the phosphate backbone of DNA and the uncharged ligands penetrate the helix and disrupt base pairing. Mobility shifts in electrophoresis, molecular dynamics, and UV-vis spectrophotometry give clues to the details of the interactions.
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