期刊
ADVANCED MATERIALS
卷 24, 期 13, 页码 1742-1747出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201104330
关键词
nanomedicine; protein particles; recombinant proteins; cell therapy; nanopills
类别
资金
- MICINN [BFU2010-17450]
- AGAUR [SGR2009-108, SGR2009-997]
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
- Instituto de Salud Carlos III
- ICREA ACADEMIA (from ICREA, Catalonia, Spain)
- Programa Personal de Tecnico de Apoyo (Modalidad Infraestructuras cientifco-tecnologicas, MICINN)
Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.
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