期刊
ADVANCED MATERIALS
卷 24, 期 28, 页码 3864-3869出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201200607
关键词
platelets; targeted drug delivery; polymeric particles; layer-by-layer technique; GPIb; VWF domain
类别
资金
- Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-0001]
- National Institutes of Health of the USA [HL-42846, HL-78784, HL-80718]
- Government of Catalonia [AGAUR FI2005, BE-2 2006]
Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and diagnostic applications for platelet associated disorders.
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