Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules

Enzyme-responsive protein nanocapsules are synthesized to release their protein cargoes in response to specific enzymes secreted in certain cellular events with both specificity and with a controlled rate by composition tuning. The unique nanocapsule structures protect the encapsulated proteins during hydrogel synthesis, providing a new direction for responsive protein delivery according to specific cellular events or the local environment.