期刊
ADVANCED MATERIALS
卷 24, 期 1, 页码 125-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201103205
关键词
peptide sensor; cyclin A2; electrochemistry; impedance; graphene
类别
资金
- 973 Project [2011CB936004, 2012CB720602]
- NSFC [20831003, 90813001, 20833006, 90913007]
- CAS
- Key Laboratory of Pesticide & Chemical Biology
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Hirao Taro Foundation of the Konan University Association for Academic Research
- Long-Range Research Initiative Project of Japan Chemical Industry Association
- Grants-in-Aid for Scientific Research [23651130, 21245040, 24655161] Funding Source: KAKEN
Using a porphyrin-functionalized graphenemodifi ed electrode, an electrochemical impedance peptide sensor for labelfree detection of cyclin A2 has been constructed. This electrochemical sensor can not only detect protein in cancer cells but also differentiate cancer cells from normal ones. Furthermore, the assay provides the potential of using a simple electrochemical technique to estimate the effi ciency of anticancer drugs in cancer therapy.
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