Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces

A nanostructured platform that combines silicon nanowire arrays and DNA aptamers realizes significant capture and efficient release of T lymphocytes. An approximately two orders of magnitude enhancement in capture efficiency compared to planar surfaces is observed with good release performance. This method of capture and release provides an artful strategy to fulfill the demands of cell isolation and diagnosis.