期刊
ADVANCED MATERIALS
卷 22, 期 38, 页码 4280-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201001417
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资金
- Korea government (MEST) [2009-0079739]
- Korea Health 21 RD Project [A062254]
- Korea Health Promotion Institute [A062254] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0079739] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.
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