期刊
ADVANCED MATERIALS
卷 22, 期 43, 页码 4851-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201001525
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- Dept. of Defense [DAAD19-02-D-0002, W911NF-07-D-0004]
- Ragon Institute of MGH, MIT, and Harvard
- NIH
Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer selfassembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP-green).
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