4.8 Article

Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery

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ADVANCED MATERIALS
卷 22, 期 21, 页码 2358-2362

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200903439

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  1. National Institutes of Health
  2. UC
  3. Stanford CIS

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A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic bio-compatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.

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