4.8 Article

Dual-Sensitive Micellar Nanoparticles Regulate DNA Unpacking and Enhance Gene-Delivery Efficiency

期刊

ADVANCED MATERIALS
卷 22, 期 23, 页码 2556-2560

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200903933

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资金

  1. National Institutes of Health
  2. National Institute of General Medical Sciences [GM073937]
  3. National Institute of Biomedical Imaging and Bioengineering [HL089764]
  4. National Science Foundation [ECCS-0725528, CBET-0546012]

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Reversibly crosslinked micellar nanoparticles that are capable of releasing encapsulated DNA in response to a reduction microenvironment and physiological ionic strength are synthesized for gene delivery. The dual-sensitive nanoparticles exhibit significantly enhanced complex and colloidal stability, yield more sustained DNA unpacking in cytosols, and mediate enhanced and more prolonged transgene expression for at least 10 days.

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