4.8 Article

Endothelial Cell Guidance in 3D Patterned Scaffolds

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ADVANCED MATERIALS
卷 22, 期 43, 页码 4831-+

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WILEY-BLACKWELL
DOI: 10.1002/adma.201001855

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  1. Natural Sciences and Engineering Research Council (NSERC)
  2. Canadian Institute of Health Research (CIHR)
  3. Japanese long-term study abroad scholarship
  4. Canadian Council

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Primary endothelial cells are guided in an agarose hydrogel scaffold that is chemically patterned with an immobilized concentration gradient of VEGF165 using multiphoton laser patterning. It is particularly compelling that, in this 3D patterned hydrogel, endothelial cells differentiate to tip and stalk cells, having the morphology that is observed in vivo.

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