期刊
ADVANCED MATERIALS
卷 21, 期 4, 页码 419-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200801393
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资金
- National Science Foundation (NSF) [CMMI-0754463]
- AFOSR
- ONR
- Ohio Supercomputer Center
- Singapore-MIT Alliance and the Interdisciplinary Research Group on Infectious Diseases
- Singapore-MIT Alliance for Research and Technology
- National Heart Lung and Blood Institute of the NIH [HL80711]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [754463] Funding Source: National Science Foundation
The cellular uptake of nanoparticles by living cells is predicted to be strongly size-dependent, according the thermodynamic analysis, and an optimal particle radius of similar to 25-30 nm at which the cellular uptake reaches a maximum of several thousand is shown to exist. The theoretical prediction provides valuable guidance for the rational design of nanoparticle-based drug-delivery systems.
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