A Class of Cationic Triblock Amphiphilic Oligopeptides as Efficient Gene-Delivery Vectors

A new class of triblock oligopeptides, containing arginine for DNA binding, histidine for intracellular buffering, and hydrophobic residues for enhanced cellu lar uptake has been designed, with each block offering unique functionalities essential for efficient gene delivery. Together, these materials demonstrate strong DNA binding ability, low cytotoxicity, and significantly higher in vivo gene-transfection efficiency compared to the PEI standard.