期刊
ADVANCED MATERIALS
卷 20, 期 16, 页码 3034-3038出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200702308
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A novel assay for measuring time-dependant ligand-receptor affinity changes is developed based on a peptide-immobilized temperature-responsive surface, as schematically illustrated in the figure. The grafted thermoresponsive polymer acts as an on-off switch for mediating integrin-peptide bonding. At temperatures above and below the lower critical solution temperature (LCST), the peptides are accessible and shielded from integrin access, respectively.
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