期刊
ADVANCED MATERIALS
卷 20, 期 17, 页码 3263-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200703181
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资金
- US Department of Energy [DE-FG02-01-ER63179]
- NSF [DMR-0117792, CTS-0120978, DMI-0328162]
- Illinois Waste Management and Research Center (WMRC)
In the presence of Pb2+, a cleaved enzyme-substrate complex releases ssDNA that adsorbs onto and stabilizes gold nanoparticles (AuNPs) against salt-induced aggregation. In the absence of Pb2+, the uncleaved complex can not stabilize the AuNPs, resulting in purple-blue AuNP aggregates (see figure). The sensor has a low detection limit of 3 nM, a high selectivity, and a tunable dynamic range.
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