Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D

A combinatorial method for screening cell-biomaterial interactions in 3D is presented; polymeric, salt-leached scaffolds with varied composition and properties are present in a 96-well plate. Previous high-throughput approaches for screening cell-material interactions have focused on planar 2D surfaces or films. However, biomaterials are commonly used in a 3D scaffold format and cells behave more physiologically when cultured in 3D.