期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201805225
关键词
chemo-photothermal therapy; controlled drug release; surface charge flipping; synergy; triple-negative breast cancer
类别
资金
- Natural Science Foundation of China [21877049]
- National Program for Support of Top-notch Young Professionals [W02070191]
- YangFan Innovative & Entrepreneurial Research Team Project [201312H05]
- Fundamental Research Funds for the Central Universities
Owing to the highly malignant and invasive innate character of triple-negative breast cancers (TNBCs), it is easy to relapse after chemotherapy; thus, there are still no effective and specific targeted therapies. In this study, a carbon nanotube (CNT)-based nanosystem Se@CNTs with surface charge flipping and targeted ability is rationally designed and successfully synthesized for precise chemo-photothermal synergistic therapy of TNBCs. The acid-labile beta-carboxylic acid group is used to reversibly functionalize the amine groups, thus forming charge-reversal nanoparticles to enhance the bioresponsive cellular uptake. The internalized Se@CNTs combined with laser irradiation induces reactive oxygen species (ROS) overproduction, which activates apoptosis-related proteins to trigger cancer cell apoptosis synergistically. Meanwhile, Se@CNTs also suppresses the invasion and migration of TNBC cells by regulating the related signaling pathways. Importantly, in combination with laser irradiation, Se@CNTs effectively inhibits the tumor growth, as demonstrated by the high tumor ablation activity in vivo through chemo-phototherapy, but shows no significant histological change in the main organs. Taken together, this study provides a strategy for rational design of next-generation nanomedicines for precise chemo-photothermal synergistic therapy of malignant TNBCs.
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