期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 43, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201803924
关键词
Ag2S nanoparticles; early tumor detection; luminescence thermometry; NIR in vivo imaging
类别
资金
- Spanish Ministry of Economy and Competitiveness [MAT2016-75362-C3-1-R, MAT2017-85617-R]
- Instituto de Salud Carlos III [PI16/00812]
- COST Action [CM1403]
- Comunidad Autonoma de Madrid [B2017/BMD-3867RENIM-CM]
- European Comission (NanoTBTech)
- European Union
- Community of Madrid [PEJD-2017-PRE/IND-3663]
- Severo Ochoa Program for Centers of Excellence in RD [SEV-2016-0686]
- CNPq (Conselho Nacional de Densenvolvimento Cientifico e Tecnologico, Brazil)
- Universidad Autonoma de Madrid, Spain [PVEA077/2013]
- PVE (Pesquisador Visitante Especial) of the Project [A077/2013]
- CAPES (Coordenadoria de Aperfeicoamento de Pessoal de Ensino Superior, Brazil)
- PDSE-CAPES program at Universidad Autonoma de Madrid, Spain [88881.134486/2016-01]
- UAM-Santander Yerun Projects
The development of technologies capable of early tumor detection is unquestionably demanded by physicians, as early diagnosis is key to achieve more efficient and less invasive treatments with improved outcomes. At the preclinical level, nanotechnology has already provided innovative solutions for tumor imaging and therapy, but it has failed to provide real early tumor diagnosis. In this work, an infrared nanothermometry-based approach toward early melanoma detection, based on the changes produced in the thermal relaxation dynamics of tissues as the tumor develops, is introduced. In vivo experiments demonstrate that detection of incipient tumors from their very onset is possible through monitoring changes in their thermal relaxation dynamics using Ag2S infrared luminescent nanothermometers. For a total tumor development time of 14 days, luminescence nanothermometry allows tumor detection 6 days before its presence is evident by visual inspection. Simultaneous study of the tumoral vasculature reveals that the premature variation in the thermal relaxation dynamics is a consequence of the interplay between tumor angiogenesis and necrosis during the different tumor development stages.
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