期刊
ADVANCED FUNCTIONAL MATERIALS
卷 24, 期 26, 页码 4144-4155出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201400080
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资金
- National Science Council of the Republic of China, Taiwan [NSC 102-2221-E-009 -023 -MY3, NSC 102-2218-E-007-014]
- Aim for the Top University program of the National Chiao Tung University
- Ministry of Education, Taiwan, R.O.C.
- Army Medical Research & Material Command [W81XWH-10-1-0320, W81XWH-10-1-0604]
A novel photo-responsive protein-graphene-protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one-component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 mu mol g(-1)) to be later unloaded in a burst-like manner by photo-actuation triggered by near-infrared irradiation. Being bio-compatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light-treating area but also widely light-omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local-targeting, on-demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.
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