期刊
ADVANCED FUNCTIONAL MATERIALS
卷 24, 期 39, 页码 6145-6153出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201401166
关键词
aptamers; sensors; bisphenol A; polypyrrole; field-effect transistors; biomedical applications; hierarchical structures
类别
资金
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2011-0017125]
- National Research Foundation of Korea [2011-0017125] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
An endocrine disruptor (ED) is a type of xenobiotic compound that can cause serious diseases related to the estrous cycle, as well as various types of cancer. At low ED concentrations, estrogen receptors may respond as they would under physiological conditions. In this work, aptamer-functionalized multidimensional conducting-polymer (3-carboxylate polypyrrole) nanoparticles (A_M_CPPyNPs) are fabricated for use in an FET sensor to detect bisphenol A (BPA). The multidimensional system, M_CPPyNPs, is first produced by means of dual-nozzle electrospray of pristine CPPyNPs and vapor deposition polymerization of additional conducting polymer. The M_CPPyNPs are then immobilized on an amine-functionalized (-NH2) interdigitated-array electrode substrate, through the formation of covalent bonds with amide groups (-CONH). The amine-functionalized BPA-binding aptamer is then introduced in the same way as that for M_CPPyNP immobilization. The resulting A_M_CPPyNP-based FET sensors exhibit ultrasensitivity and selectivity towards BPA at unprecedentedly low concentrations (1 fm) and among molecules with similar structures. Additionally, due to the covalent bonding involved in the immobilization processes, a longer lifetime is expected for the FET sensor.
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