期刊
ADVANCED FUNCTIONAL MATERIALS
卷 24, 期 29, 页码 4584-4594出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201400653
关键词
MRI; magnetic nanoparticles; magnetic guidance; relaxivity; mesoporous matrices
类别
资金
- Cancer Prevention Research Institute of Texas [CPRIT RP110262]
- National Institutes of Health (USA) (NIH) [U54CA143837, U54CA151668]
- Welch Foundation [C-0627]
- Italian Ministry of Research (FIRB) [RBFR10VZUG]
- European Social Fund
- Regione Calabria (POR Calabria FSE)
- DoD/BCRP [W81XWH-09-1-0212]
- Ernest Cockrell Jr. Distinguished Endowed Chair
Iron oxide nanoparticles are formidable multifunctional systems capable of contrast enhancement in magnetic resonance imaging, guidance under remote fields, heat generation, and biodegradation. Yet, this potential is underutilized in that each function manifests at different nanoparticle sizes. Here, sub-micrometer discoidal magnetic nanoconstructs are realized by confining 5 nm ultra-small super-paramagnetic iron oxide nanoparticles (USPIOs) within two different mesoporous structures, made out of silicon and polymers. These nanoconstructs exhibit transversal relaxivities up to approximate to 10 times (r(2) approximate to 835 mm (-1) s(-1)) higher than conventional USPIOs and, under external magnetic fields, collectively cooperate to amplify tumor accumulation. The boost in r(2) relaxivity arises from the formation of mesoscopic USPIO clusters within the porous matrix, inducing a local reduction in water molecule mobility as demonstrated via molecular dynamics simulations. The cooperative accumulation under static magnetic field derives from the large amount of iron that can be loaded per nanoconstuct (up to approximate to 65 fg) and the consequential generation of significant inter-particle magnetic dipole interactions. In tumor bearing mice, the silicon-based nanoconstructs provide MRI contrast enhancement at much smaller doses of iron (approximate to 0.5 mg of Fe kg(-1) animal) as compared to current practice.
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