期刊
ADVANCED FUNCTIONAL MATERIALS
卷 23, 期 47, 页码 5833-5839出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201300483
关键词
osteoarthritis; tissue engineering; hydrogels; synthetic cartilage; 3D weaving; scaffolds
类别
资金
- National Institutes of Health [AG15768, AR50245, AR48182, AR48852]
- Arthritis Foundation
- Collaborative Research Center, AO Foundation, Davos, Switzerland
- NSF [CMMI-1253495, CMMI-1200515, DMR-1121107]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1253495, 1463732, 1200515] Funding Source: National Science Foundation
The development of synthetic biomaterials that possess mechanical properties mimicking those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelastic, and anisotropic material that exhibits a very low coefficient of friction, allowing it to withstand millions of cycles of joint loading over decades of wear. Here, a three-dimensionally woven fiber scaffold that is infiltrated with an interpenetrating network hydrogel can build a functional biomaterial that provides the load-bearing and tribological properties of native cartilage. An interpenetrating dual-network tough-gel consisting of alginate and polyacrylamide was infused into a porous three-dimensionally woven poly(E-caprolactone) fiber scaffold, providing a versatile fiber-reinforced composite structure as a potential acellular or cell-based replacement for cartilage repair.
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