期刊
ADVANCED FUNCTIONAL MATERIALS
卷 24, 期 12, 页码 1738-1747出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201302433
关键词
nanoscale coordination polymers; magnetic resonance imaging; dual contrast; tumor imaging
类别
资金
- National Natural Science Foundation of China [21271130]
- program for Changjiang Schloars and Innovative Research Team in University [IRT1269]
- Key Subject of Education Ministry of China [210075]
- Shanghai Natural Science Fund Project [12ZR1421800]
- Shanghai Municipal Education Commission [13ZZ110]
- Shanghai Normal University [DXL122, DYL20B05, SK201339]
Development of multifunctional nanoscale coordination polymers (NCPs) allowing for T-1- and T-2-weighted targeted magnetic resonance (MR) imaging of tumors could significantly improve the diagnosis accuracy. In this study, nanoscale coordination polymers (NCPs) with a diameter of approximate to 80 nm are obtained with 1,1-dicarboxyl ferrocene (Fc) as building blocks and magnetic gadolinium(III) ions as metallic nodes using a nanoprecipitation method, then further aminated through silanization. The amine-functionalized Fc-Gd@SiO2 NCPs enable the covalent conjugation of a fluorescent rhodamine dye (RBITC) and an arginine-glycine-aspartic acid (RGD) peptide as a targeting ligand onto their surface. The formed water-dispersible Fc-Gd@SiO2(RBITC)-RGD NCPs exhibit a low cytotoxicity, as confirmed by MTT assay. They have a longitudinal relaxivity (r(1)) of 5.1 mM(-1) s(-1) and transversal relaxivity (r(2)) of 21.7 mM(-1) s(-1), suggesting their possible use as both T-1-positive and T-2-negative contrast agents. In vivo MR imaging experiments show that the signal of tumor over-expressing high affinity (v3) integrin from T-1-weighted MR imaging is positively enhanced 47 +/- 5%, and negatively decreased 33 +/- 5% from T-2-weighted MR imaging after intravenous injection of Fc-Gd@SiO2(RBITC)-RGD NCPs.
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