期刊
ADVANCED FUNCTIONAL MATERIALS
卷 24, 期 11, 页码 1624-1630出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201301649
关键词
nucleoside triphosphates; nanoceria; oxidase; phosphatase; coupling reactions; SNPs
类别
资金
- 973 Project [2011CB936004, 2012CB720602]
- NSFC [21210002, 91213302]
Nucleoside triphosphates (NTPs) can improve the oxidase-like activity of nanoceria and the enhancement is correlated with the type of NTP. This effect is demonstrated to be as a result of the coupling of the oxidative reaction with the NTP hydrolysis reactions, as the nanoceria has both oxidase-like and phosphatase-like activities. The differences reflect the different dephosphorylation catalytic activities of nanoceria to the NTP used. Furthermore, based on the NTP-promoted oxidase-like activity of nanoceria and the differences among the different types of NTPs, series effective and high-throughput colorimetric assays for single-nucleotide polymorphism (SNP) typing are developed.
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