期刊
ADVANCED FUNCTIONAL MATERIALS
卷 23, 期 33, 页码 4067-4078出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201300136
关键词
pH; thermo coupling sensitivity; N-isopropylacrylamide; drug delivery; up-conversion; cell imaging
类别
资金
- National Basic Research Program of China [2010CB327704]
- National High Technology Program of China [2011AA03A407]
- National Natural Science Foundation of China [NSFC 51172228, 51272248, 20901074, 21221061]
- Science Technology Development Program of Jilin Province for Youths [20100106]
Multifunctional nanocarriers based on the up-conversion luminescent nanoparticles of NaYF4:Yb3+/Er3+ core (UCNPs) and thermo/pH-coupling sensitive polymer poly[(N-isopropylacrylamide)-co-(methacrylic acid)] (P(NIPAm-co-MAA)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. The as-synthesized hybrid nanospheres UCNPs@mSiO(2)-P(NIPAm-co-MAA) show bright green up-conversion fluorescence under 980 nm laser excitation and the thermo/pH-sensitive polymer is active as a valve to moderate the diffusion of the embedded drugs in-and-out of the pore channels of the silica container. The anticancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO(2)-P(NIPAm-co-MAA) nanospheres and the composite drug delivery system (DDS) shows a low level of leakage at low temperature/high pH values but significantly enhanced release at higher temperature/lower pH values, exhibiting an apparent thermo/pH controlled on-off drug release pattern. The as-prepared UCNPs@mSiO(2)-P(NIPAm-co-MAA) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. The reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli-responsive controlled drug delivery.
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