期刊
ADVANCED FUNCTIONAL MATERIALS
卷 23, 期 5, 页码 575-582出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201201902
关键词
functional biomaterials; poly(ethylene glycol); -cyclodextrin; tissue engineering; hydrogels
类别
资金
- Maryland Stem Cell Research Foundation
- National Science Foundation [CMMI 0948053]
- Jules Stein Chair
- National Institutes of Health [NIDCR R01DE016887]
Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue engineering. Chemical modification is required to input biological or chemical ligands, which often changes the fundamental structural properties of the material. Here, a simple modular biomaterial design strategy is reported that employs functional cyclodextrin nanobeads threaded onto poly(ethylene glycol) (PEG) polymer necklaces to form multifunctional hydrogels. Nanobeads with desired chemical or biological functionalities can be simply threaded onto the PEG chains to form hydrogels, creating an accessible platform for users. The design and synthesis of these multifunctional hydrogels are described, structure-property relationships are elucidated, and applications ranging from stem cell culture and differentiation to tissue engineering are demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据