期刊
ADVANCED FUNCTIONAL MATERIALS
卷 22, 期 22, 页码 4711-4717出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201201156
关键词
polydopamine; self-assembly; 5; 6-dihydroxyindole; melanin; cytotoxicity
类别
资金
- National Research Foundation of South Korea: WCU Program [R31-10071]
- National Research Foundation of South Korea: Basic Science Research Program [2012-0000909]
- National Research Foundation of South Korea: Bio & Medical Technology Development Program [2012-0006085]
- National Research Foundation of South Korea: Fostering Core Leaders of the Future Basic Science Program [2012H1A8002613]
- Chung-Am Fellowship
- National Research Foundation of Korea [2009-0093117, 2009-0092222, R31-2012-000-10071-0, 2012H1A8002613] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Polydopamine is the first adhesive polymer that can functionalize surfaces made of virtually all material chemistries. The material-independent surface modification properties of polydopamine allow the functionalization of various types of medical and energy devices. However, the mechanism of dopamine polymerization has not yet been clearly demonstrated. Covalent oxidative polymerization via 5,6-dihydroxyindole (DHI), which is similar to the mechanism for synthetic melanin synthesis, has been the clue. Here, it is reported that a physical, self-assembled trimer of (dopamine)2/DHI exists in polydopamine, which has been known to be formed only by covalent polymerization. It is also found that the trimeric complex is tightly entrapped within polydopamine and barely escapes from the polydopamine complex. The result explains the previously reported in vitro and in vivo biocompatibility. The study reveals a different perspective of polydopamine formation, where it forms in part by the self-assembly of dopamine and DHI, providing a new clue toward understanding the structures of catecholamines such as melanin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据