期刊
ADVANCED FUNCTIONAL MATERIALS
卷 22, 期 7, 页码 1446-1453出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201102737
关键词
capsules; hemoglobin; biocompatibility; hemocompatibility; blood substitutes
类别
资金
- National Nature Science Foundation of China [20833010, 21003136]
- National Basic Research Program of China (973 program) [2009CB930101]
Hemoglobin-based capsules for use as blood substitutes are successfully fabricated by covalent layer-by-layer assembly. Dialdehyde heparin (DHP) is used both as one of the wall components and a cross-linker without employing other extraneous or toxic crosslinking agents. The biocompatibility of (Hb/DHP)6 microcapsules is evaluated through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and cell experiments. The hemocompatibility of (Hb/DHP)6 microcapsules is characterized in terms of prothrombin time, thrombin time, activated partial thromboplastin time, and hemolysis rate. The oxygen-carrying capacity of the microcapsules is demonstrated by converting the deoxy-Hb state of the microcapsules into the oxy-Hb state. All these results demonstrate that the hemoglobin-based microcapsules exhibit oxygen-carrying capacity as well as biocompatibility and hemocompatility, indicating that the as-prepared capsules have great potential to function as blood substitutes.
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