期刊
ADVANCED FUNCTIONAL MATERIALS
卷 22, 期 15, 页码 3181-3190出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201200457
关键词
poly(propylene fumarate) (PPF); polyhedral oligomeric silsesquioxane (POSS); photo-crosslinking; mechanical properties; MC3T3-E1 cell functions
类别
资金
- University of Tennessee
- Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy [CNMS2012-R14]
A series of novel injectable and photo-crosslinkable poly(propylene fumarate) (PPF)-co-polyhedral oligomeric silsesquioxane (POSS) copolymers are synthesized via two-step polycondensation to improve both stiffness and toughness and to promote biological performance of bone tissue engineering scaffolds. The viscoelastic behavior of uncrosslinked PPF-co-POSS and the thermal, mechanical, and surface characteristics of photo-crosslinked PPF-co-POSS are investigated as well as the degradation behavior and microscopic POSS domain structures at various weight compositions of POSS (?POSS). Tensile and compressive moduli and facture toughness are enhanced for crosslinked PPF-co-POSS when POSS nanocages are well distributed and their crystallinity is completely confined in the networks. Decreases in these mechanical properties are observed at higher ?POSS because of decreased crosslinking density and larger POSS aggregates. The mechanical properties are correlated with in vitro mouse pre-osteoblastic MC3T3-E1 cell functions including cell attachment, spreading, proliferation, differentiation, and gene expression, which all maximize at ?POSS of 10%.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据