期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 9, 页码 5605-5611出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b01069
关键词
graphene oxide; dental-pathogens; antibacterial material; Streptococcus mutans; Fusobacterium nucleatum; Porphyromonas gingivalis
资金
- Shanghai Natural Science Foundation [13ZR1423900]
- Hospital-Public Cross-Link Project of Shanghai Jiao Tong University [YG2013MS58]
Dental caries and periodontal diseases have a close relationship with microbes such as Streptococcus mutans, Porphyromonas gingivalis and Fusobacterium nucleatum. Graphene oxide (GO), as the derivative of graphene, plays an important role in many areas including biology and medicine. In particular, it has been known as a promising antimicrobial nanomaterial. In this study, we focused on the antimicrobial property of GO against dental pathogens. With the utilization of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduced test, colony forming units (CFU) counting, growth curve observation, live/dead fluorescent staining, and confocal laser scanning microscopy (CLSM), we found GO nanosheets were highly effective in inhibiting the growth of dental pathogens. Transmission electron microscopy (TEM) images revealed that the cell wall and membrane of bacteria lost their integrity and the intracellular contents leaked out after they were treated by GO. Therefore, GO nanosheets would be an effective antibacterial material against dental pathogens and the potential applications in dental care and therapy are promising.
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