期刊
ADVANCED FUNCTIONAL MATERIALS
卷 21, 期 22, 页码 4295-4304出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201101557
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- Israeli Ministry of Industry
The design and synthesis of novel hybrid-silica nanoparticles (NPs) containing the FDA-approved antimicrobial triclosan (Irgasan) covalently linked within the inorganic matrix for its controlled, slow release upon interaction, is reported. The NPs are in the range of 130 +/- 30 nm in diameter, with a smooth and spherical morphology. Characterization of the hybrid-silica NPs containing triclosan, namely T-SNPs, and their appropriate linkers is accomplished by microscopic and spectroscopic techniques. Preliminary antimicrobial activity is studied through bacterial-growth experiments. The T-SNPs are found to be superior in killing bacteria, as compared with the free biocide.
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