期刊
ADVANCED FUNCTIONAL MATERIALS
卷 19, 期 14, 页码 2312-2318出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.200801904
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资金
- NIH Director's Pioneer Award [5DP10D000798]
- Washington University in St. Louis
- School of Materials Science and Engineering, Tianjin University, Tianjin
- National Council of Scholarship
Conductive core-sheath nanofibers are prepared by a combination of electrospinning and aqueous polymerization. Specifically, nanofibers electrospun from poly(c-caprolactone) (PCL) and poly(L-lactide) (PLA) are employed as templates to generate uniform sheaths of polypyrrole (PPy) by in-situ polymerization. These conductive core-sheath nanofibers; offer a unique system to study the synergistic effect of different cues on neurite outgrowth in vitro. It is found that explanted dorsal root ganglia (DRG) adhere well to the conductive core-sheath nanofibers and generate neurites across the surface when there is a nerve growth factor in the medium. Furthermore, the neurites can be oriented along one direction and enhanced by 82% in terms of maximum length when uniaxially aligned conductive core-sheath nanofibers; are compared with their random counterparts. Electrical stimulation, when applied through the mats of conductive core-sheath nanofibers, is found to further increase the maximum length of neurites for random and aligned samples by 83% and 47%, respectively, relative to the controls without electrical stimulation. Together these results suggest the potential use of the conductive core-sheath nanofibers as scaffolds in applications such as neural tissue engineering.
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