Uniform Rattle-type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained-Release Property

A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H, reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g(-1) when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-re lease property, which follows a Fick's law.