期刊
ADVANCED FUNCTIONAL MATERIALS
卷 18, 期 22, 页码 3568-3582出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.200800662
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资金
- NIH [NIDCR DE017689, NIDCR DE015384, NIGMS GM075840]
Biomaterials play a pivotal role in regenerative medicine, which aims to regenerate and replace lost/dysfunctional tissues or organs. Biomaterials (scaffolds) serve as temporary 3D substrates to guide neo tissue formation and organization. It is often beneficial for a scaffolding material to mimic the characteristics of extracellular matrix (ECM) at the nanometer scale and to induce certain natural developmental or/and wound healing processes for tissue regeneration applications. This article reviews the fabrication and modification technologies for nanofibrous, nanocomposite, and nanostructured drug-delivering scaffolds. ECM-mimicking nanostructured biomaterials have been shown to actively regulate cellular responses including attachment, proliferation, differentiation, and matrix deposition. Nanoscaled drug delivery systems can be successfully incorporated into a porous 3D scaffold to enhance the tissue regeneration capacity. In conclusion, nanostructured biomaterials are a very exciting and rapidly expanding research area, and are providing new enabling technologies for regenerative medicine.
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