期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 132, 期 -, 页码 214-234出版社
ELSEVIER
DOI: 10.1016/j.addr.2018.07.015
关键词
Hydrogels; Fibrous networks; Fibre reinforcement; Functional tissue engineering; Composites; Soft matrix composites
资金
- ARC Industrial Transformation Training Centre in Additive Biomanufacturing [IC160100026]
- Queensland University of Technology (QUT)
- Hans Fischer Senior Fellowship at the Institute for Advanced Study, Technische Universitat Munchen
Developing multifunctional soft biomaterials capable of addressing all the requirements of the complex tissue regeneration process is a multifaceted problem. In order to tackle the current challenges, recent research efforts are increasingly being directed towards biomimetic design concepts that can be translated into soft biomaterials via advanced manufacturing technologies. Among those, soft network composites consisting of a continuous hydro gel matrix and a reinforcing fibrous network closely resemble native soft biological materials in terms of design and composition as well as physicochemical properties. This article reviews soft network composite systems with a particular emphasis on the design, biomaterial and fabrication aspects within the context of soft tissue engineering and drug delivery applications. (C) 2018 Published by Elsevier B.V.
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