期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 72, 期 -, 页码 127-143出版社
ELSEVIER
DOI: 10.1016/j.addr.2014.01.007
关键词
Sonophoresis; Transdermal drug delivery; Ultrasound; Transport phenomena; Models and simulations; Synergistic effects of ultrasound; Safety
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin. Application of ultrasound (US) irradiation to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis in transdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field. Particular attention is paid to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy. (C) 2014 Elsevier B.V. All rights reserved.
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