期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 71, 期 -, 页码 115-130出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2014.01.004
关键词
Gene therapy; Nanomedicine; Biomaterials; Tissue engineering; Cardiovascular
资金
- Natural Sciences and Engineering Research Council (NSERC, Canada)
- Canadian Institutes of Health Research (CIHR) [MOP 93641]
- NSERC-Michael Smith Foreign Study graduate award
- FRQS (Fonds de recherche du Quebec - Sante) postdoctoral award
- NSERC postdoctoral award
- FRQS doctoral award
Designing a safe and efficient gene delivery system is required for success of gene therapy trials. Although a wide variety of viral, non-viral and polymeric nanoparticle based careers have been widely studied, the current gene delivery vehicles are limited by their suboptimal, non-specific therapeutic efficacy and acute immunological reactions, leading to unwanted side effects. Recently, there has been a growing interest in insect-cell-originated baculoviruses as gene delivery vehicles for diverse biomedical applications. Specifically, the emergence of diverse types of surface functionalized and bioengineered baculoviruses is posed to edge over currently available gene delivery vehicles. This is primarily because baculoviruses are comparatively non-pathogenic and non-toxic as they cannot replicate in mammalian cells and do not invoke any cytopathic effect. Moreover, emerging advanced studies in this direction have demonstrated that hybridizing the baculovirus surface with different kinds of bioactive therapeutic molecules, cell-specific targeting moieties, protective polymeric grafts and nanomaterials can significantly improve the preclinical efficacy of baculoviruses. This review presents a comprehensive overview of the recent advancements in the field of bioengineering and biotherapeutics to engineer baculovirus hybrids for tailored gene therapy, and articulates in detail the potential and challenges of these strategies for clinical realization. In addition, the article illustrates the rapid evolvement of microfluidic devices as a high throughput platform for optimizing baculovirus production and treatment conditions. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据