期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 78, 期 -, 页码 3-13出版社
ELSEVIER
DOI: 10.1016/j.addr.2014.08.003
关键词
Antimicrobial resistance; Methicillin-resistant Staphylococcus aureus; Vancomycin-resistant enterococci; Carbapenem resistance; Enterobacteriaceae; beta-Lactamases; Acinetobacter baumannii
Alexander Fleming's discovery of penicillin heralded an age of antibiotic development and healthcare advances that are premised on the ability to prevent and treat bacterial infections both safely and effectively. The resultant evolution of antimicrobial resistant mechanisms and spread of bacteria bearing these genetic determinants of resistance are acknowledged to be one of the major public health challenges globally, and threatens to unravel the gains of the past decades. We describe the major mechanisms of resistance to beta-lactam antibiotics - the most widely used and effective antibiotics currently - in both Gram-positive and Gram-negative bacteria, and also briefly detail the existing and emergent pharmacological strategies to overcome such resistance. The global epidemiology of the four major types of bacteria that are responsible for the bulk of antimicrobial-resistant infections in the healthcare setting - methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci. Enterobactericeae, and Acinetobacter baumannii - are also briefly described. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据