期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 1, 页码 17-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.07.015
关键词
Hydrogels; Smart hydrogels; Self-regulated drug delivery; Clinical applications; Mimicking natural systems
资金
- NIH [CA129287, GM095879]
- Showalter Research Trust Fund
Since 1960 when the history of modern hydrogels began significant progress has been made in the field of controlled drug delivery. In particular, recent advances in the so-called smart hydrogels have made it possible to design highly sophisticated formulations, e.g., self-regulated drug delivery systems. Despite intensive efforts, clinical applications of smart hydrogels have been limited. Smart hydrogels need to be even smarter to execute functions necessary for achieving desired clinical functions. It is necessary to develop novel hydrogels that meet the requirements of the intended, specific applications, rather than finding applications of newly developed hydrogels. Furthermore, developing smarter hydrogels that can mimic natural systems is necessary, but the fundamental differences between natural and synthetic systems need to be understood. Such understanding will allow us to develop novel hydrogels with the new, multiple functions that we are looking for. (c) 2012 Elsevier B.V. All rights reserved.
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