期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 9, 页码 1215-1233出版社
ELSEVIER
DOI: 10.1016/j.addr.2013.05.001
关键词
Cyclodextrin; Amphiphile; Self-assembly; Supramolecular system; Nanoparticle; Nanomedicine; Hydrogel; Drug delivery; Gene therapy
资金
- NIH (NIDCR) [DE022327, DE015384]
- NIH (NHLBI) [HL114038]
- DOD [W81XWH-12-2-0008]
- NSF [DMR-1206575]
- National Natural Science Foundation of China [81271695, 21004077]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL114038] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE022327] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE015384] Funding Source: NIH RePORTER
The excellent biocompatibility and unique inclusion capability as well as powerful functionalization capacity of cyclodextrins and their derivatives make them especially attractive for engineering novel. functional materials for biomedical applications. There has been increasing interest recently to fabricate supramolecular systems for drug and gene delivery based on cyclodextrin materials. This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery. First, we introduce cyclodextrin materials utilized for self-assembly. The fabrication technologies of supramolecular systems including nanoplatforms and hydrogels as well as their applications in nanomedicine and pharmaceutical sciences are then highlighted. At the end, the future directions of this field are discussed. (C) 2013 Elsevier B.V. All rights reserved.
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