期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 13-14, 页码 1699-1715出版社
ELSEVIER
DOI: 10.1016/j.addr.2013.04.011
关键词
Stimuli; Responsive; Drug delivery; Multidrug resistance; Tumor; Chemotherapy
资金
- National Basic Research Program of China [2010CB934000, 2013CB932704, 2013CB932503]
- National Natural Science Foundation of China [30925041, 81230029]
- Shanghai Science and Technology Innovation Action Plan [11nm0505900]
Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for chemotherapy. The new drug delivery system (DDS) provides promising approaches to reverse MDR, for which the poor cellular uptake and insufficient intracellular drug release remain rate-limiting steps for reaching the drug concentration level within the therapeutic window. Stimulus-coupled drug delivery can control the drug-releasing pattern temporally and spatially, and improve the accumulation of chemotherapeutic agents at targeting sites. In this review, the applications of DDS which is responsive to different types of stimuli in MDR cancer therapy is introduced, and the design, construction, stimuli-sensitivity and the effect to reverse MDR of the stimuli-responsive DDS are discussed. (C) 2013 Elsevier B.V. All rights reserved.
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