期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 1, 页码 139-147出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.11.006
关键词
Drug delivery system; Targeted drug delivery; Pharmacokinetics; Tissue uptake clearance; Macromolecular prodrugs; Chemical modified proteins; Nanoparticles; Liposomes
Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be related to physicochemical properties of the delivery system. Various delivery systems including macromolecular drug conjugates, chemically or genetically modified proteins, and particulate drug carriers have been designed and developed so far. In this article, we review physiological and pharmacokinetic implications of the delivery systems. (C) 2013 Published by Elsevier B.V.
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