期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 11-12, 页码 1626-1663出版社
ELSEVIER
DOI: 10.1016/j.addr.2013.07.017
关键词
Microfluidics; Device fabrication; Unit operation; Scale-up; Monodisperse droplets; Parallel flow; Functional materials; Biological processing
资金
- Grants-in-Aid for Scientific Research [25420840] Funding Source: KAKEN
- Engineering and Physical Sciences Research Council [EP/H029923/1] Funding Source: researchfish
- EPSRC [EP/H029923/1] Funding Source: UKRI
Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery. (C) 2013 Elsevier B.V. All rights reserved.
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