期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 1, 页码 71-79出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.10.002
关键词
EPR effect mediators; Enhancement of the EPR effect; Tumor-selective drug delivery; Inflammation; Cancer; Vascular effectors; Fluorescent nanoprobes; Tumor blood vessel architecture
资金
- Grants-in-Aid for Scientific Research [22700927, 25430162] Funding Source: KAKEN
The EPR effect results from the extravasation of macromolecules or nanoparticles through tumor blood vessels. We here provide a historical review of the EPR effect including its features, vascular mediators found in both cancer and inflamed tissue. In addition, architectural and physiological differences of tumor blood vessels vs that of normal tissue are commented. Furthermore, methods of augmentation of the EPR effect are described, that result in better tumor delivery and improved therapeutic effect, where nitroglycerin, angiotensin I-converting enzyme (ACE) inhibitor, or angiotensin II-induced hypertension are employed. Consequently, better therapeutic effect and reduced systemic toxicity are generally observed. Obviously, the EPR effect based delivery of nanoprobes are also useful for tumor-selective imaging agents with using fluorescent or radio nuclei in nanoprobes. We also commented a key difference between passive tumor targeting and the EPR effect in tumors, particularly as related to drug retention in tumors: passive targeting of low-molecular-weight X-ray contrast agents involves a retention period of less than a few minutes, whereas the EPR effect of nanoparticles involves a prolonged retention time days to weeks. (C) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据