期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 1, 页码 21-23出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.04.010
关键词
Nanoparticles; Nanospheres; Nanocapsules; Polymers; Drug loading; Intracellular delivery; Drug targeting; Nanotheragnostics; Opsonization; Biodegradability; Cancer resistance
This opinion paper relates how nanoparticles were discovered in the seventies and how the development of biodegradable materials and nanoparticle surface functionalization has allowed new treatment strategies. The reasons why only very few nanoparticle-based medicines are on the market or in late clinical trials are discussed and some new approaches are identified. Future challenges in the nanoparticle field are also identified. (c) 2012 Elsevier B.V. All rights reserved.
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