期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 65, 期 4, 页码 559-569出版社
ELSEVIER
DOI: 10.1016/j.addr.2012.06.002
关键词
Neuro-bionics; Controlled release; Organic conductive polymers; Drug-eluting coatings; Nerve preservation; Electrode-neural interfacing; Foreign body response
资金
- Australian Research Council
- National Health and Medical Research Council
- HEARing CRC under the Australian Government's Cooperative Research Centres Program
Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used. (C) 2012 Elsevier B.V. All rights reserved.
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