期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 64, 期 11, 页码 1031-1045出版社
ELSEVIER
DOI: 10.1016/j.addr.2011.09.012
关键词
Cascade reactions; Biodegradable polymers; Depolymerization; Prodrugs; Nanoparticles; Drug delivery; Sensors
资金
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chairs Program
- Ontario Ministry of Research and Innovation Early Researcher Award
In recent years, numerous delivery systems based on polymers, dendrimers, and nano-scale assemblies have been developed to improve the properties of drug molecules. In general, for the drug molecules to be active, they must be released from these delivery systems, ideally in a selective manner at the therapeutic target. As the changes in physiological conditions are relatively subtle from one tissue to another and the concentrations of specific enzymes are often quite low, a release strategy involving the amplification of a biological signal is particularly attractive. This article describes the development of oligomers, dendrimers, and linear polymers based on self-immolative spacers. This new class of molecules is designed to undergo a cascade of intramolecular reactions in response to the cleavage of a trigger moiety, resulting in molecular fragmentation and the release of multiple reporter or drug molecules. Progress in the development of these materials as drug delivery vehicles and sensors will be highlighted. (c) 2011 Elsevier B.V. All rights reserved.
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